![]() Sometimes mast cells become defective and release mediators because of abnormal internal signals. They are called “secondary activation” because they are due to (secondary to) external stimuli. These responses, while not desirable, are made by “normal” mast cells. Mast cells can also be activated by other substances, such as medications, infections, insect or reptile venoms. Some of these mediators are stored in granules in the mast cells and are released quickly and others are made slowly only after the cell has been triggered. This triggering is called activation, and the release of these mediators is called degranulation. In allergic reactions, this release occurs when the allergy antibody IgE, which is present on the mast cell surfaces, binds to proteins that cause allergies, called allergens. They cause allergic symptoms by releasing products called “mediators” stored inside them or made by them. Mast cells are allergy cells responsible for immediate allergic reactions.
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